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SUZ12 Antibody

SUZ12 Antibody

ArtNr	PRS-7701-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Colorectal Cancer Breast Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	SUZ12 Antibody: CHET9, JJAZ1, CHET9, KIAA0160, Polycomb protein SUZ12, Chromatin precipitated E2F target 9 protein, ChET 9 protein
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Shipping	blue ice or RT
By Research Area	Stem Cell
Homology	Predicted species reactivity based on immunogen sequence: Mouse: (79%)
Immunogen	SUZ12 antibody was raised against a 19 amino acid peptide near the center of human SUZ12. The immunogen is located within amino acids 400 - 450 of SUZ12.
Applications	SUZ12 antibody can be used for detection of SUZ12 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	SUZ12 antibody is human specific.
Positive Control 1	Cat. No. 1304 - Human Liver Tissue Lysate
Positive Control 2	Cat. No. 10-101 - Human Lung Tissue Slide
Predicted Molecular Weight	Predicted: 81 kDa Observed: 96 kDa
Purification	SUZ12 antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	SUZ12 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	SUZ12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Related Products	Cat. No. 7701P – SUZ12 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	SUZ12
Accession #	NP_056170
Protein Gi #	197333809
Ncbi Gene Id #	23512
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	SUZ12
Ncbi Official Full Name	SUZ12 polycomb repressive complex 2 subunit
Ncbi Organism	homo sapiens
Swissprot #	Q15022
Background	The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1). SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2). It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. It contains one C2H2-type zinc finger region and a C-terminal VEFS-box (3, 4). SUZ12 is overexpressed in breast and colon cancer. SUZ12 may be a cause of endometrial stromal tumors (5).
Background References 1	Kirmizis A, Bartley SM, Kuzmichev A, et al. Silencing of human polycomb target genes is associated with methylation of Histone H3 Lys 27. Genes Dev. 2004; 18:1592-605.
Background References 2	Pasini D, Bracken AP, Hansen JB, et al. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell. Biol. 2007; 27:3769-79.
Background References 3	Cao R and Zhang Y. SUZ12 is required for both the Histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 2004; 15:57-67.
Background References 4	Pasini D, Bracken AP, Jensen MR, et al. SUZ12 is essential for mouse development and for EZH2 Histone methyltransferase activity. EMBO J. 2004; 23:4061-71.
1st Image Caption	Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 μ g/ml.
2nd Image Caption	Immunohistochemistry of SUZ12 in human lung tissue with SUZ12 antibody at 5 μ g/mL.
3rd Image Caption	Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 μ g/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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