ArtNr |
PRS-76-716-100tests |
Hersteller |
ProSci
|
Menge |
100 tests |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
liquid |
Applikationen |
FC |
Specific against |
Human |
Host |
Mouse |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
CD8, MAL, p32, Leu2, CD8A |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Immunology |
Specificity |
The RPA-T8 monoclonal antibody specifically reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells. |
Purification |
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Clonality |
Monoclonal |
Clone |
RPA-T8 |
Isotype |
Mouse IgG1, kappa |
Conjugate |
APC-Cy7 |
Buffer |
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
Concentration |
batch dependent |
Storage Conditions |
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
CD8A |
Ncbi Gene Id # |
925 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
CD8A |
Ncbi Official Full Name |
CD8a molecule |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P01732 |
Background |
The RPA-T8 monoclonal antibody specifically reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells. CD8 interacts with the major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. The RPA-T8 antibody reacts with 13-48% of peripheral lymphocytes, 80% of thymocytes, and a subset of natural killer cells. RPA-T8, OKT8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance. |
Background References 1 |
Lefrancois, L. (1991). Phenotypic complexity of intraepithelial lymphocytes of the small intestine.The Journal of Immunology, 147(6), 1746-1751. |
Background References 2 |
Walker, I. D., Murray, B. J., Hogarth, P. M., Kelso, A., McKenzie, I. F. (1984). Comparison of thymic and peripheral T cell Ly‐2/3 antigens.European journal of immunology, 14(10), 906-910. |
Background References 3 |
THOMA-USZYNSKI, S., LADEL, C., KAUFMANN, S. (1997). Abscess formation in Listeria monocytogenes-infected gamma-delta T cell deficient mouse mutants involves alpha -beta T cells.Microbial pathogenesis, 22(2), 123-128. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.