ArtNr |
PRS-76-362-25tests |
Hersteller |
ProSci
|
Menge |
25 tests |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
liquid |
Applikationen |
FC |
Specific against |
Human |
Host |
Mouse |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
CD4mut, CD4 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Immunology |
Specificity |
The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). |
Purification |
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Clonality |
Monoclonal |
Clone |
RPA-T4 |
Isotype |
Mouse IgG1, kappa |
Conjugate |
PerCP-Cy5.5 |
Buffer |
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
Concentration |
batch dependent |
Storage Conditions |
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
CD4 |
Ncbi Gene Id # |
920 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
CD4 |
Ncbi Official Full Name |
CD4 molecule |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P01730 |
Background |
The RPA-T4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation, together with the MHC class II. The RPA-T4 antibody is capable of blocking HIV binding and inhibiting syncytium formation, by binding to the D1 domain of the CD4 antigen. The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding. |
Background References 1 |
Knapp W(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. |
Background References 2 |
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.