ArtNr |
PRS-76-286-100tests |
Hersteller |
ProSci
|
Menge |
100 tests |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
liquid |
Applikationen |
FC |
Specific against |
Human |
Host |
Mouse |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
T3E, TCRE, IMD18, CD3E |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Immunology |
Specificity |
The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. |
Purification |
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product. |
Clonality |
Monoclonal |
Clone |
UCHT1 |
Isotype |
Mouse IgG1, kappa |
Conjugate |
FITC |
Buffer |
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
Concentration |
batch dependent |
Storage Conditions |
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
CD3E |
Ncbi Gene Id # |
916 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
CD3E |
Ncbi Official Full Name |
CD3e molecule, epsilon (CD3-TCR complex) |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P07766 |
Background |
The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation. |
Background References 1 |
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. |
Background References 2 |
McMichael, A. J. (1987). Leucocyte typing III.Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985) |
Background References 3 |
Beverley, P. C., Callard, R. E. (1981). Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.European journal of immunology, 11(4), 329-334. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.