ArtNr |
PRS-76-031-0.1mg |
Hersteller |
ProSci
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
liquid |
Applikationen |
FC |
Specific against |
Mouse |
Host |
Rat |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Cd27l, CD27LG, Tnfsf7, Cd70 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Immunology, Functional Assays |
Specificity |
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. |
Purification |
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein. |
Clonality |
Monoclonal |
Clone |
FR70 |
Isotype |
Rat IgG2b, kappa |
Conjugate |
Unconjugated |
Buffer |
Phosphate-buffered aqueous solution, ph7.2. |
Concentration |
batch dependent |
Storage Conditions |
The product should be stored undiluted at 4˚ C . Do not freeze. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
Cd70 |
Ncbi Gene Id # |
21948 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
Cd70 |
Ncbi Official Full Name |
CD70 antigen |
Ncbi Organism |
Mus musculus |
Swissprot # |
O55237 |
Background |
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27. |
Background References 1 |
Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology, 159(10), 4959-4965. |
Background References 2 |
Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb.International immunology, 10(4), 517-526. |
Background References 3 |
Bullock, T. N., Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology, 174(2), 710-717. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.