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TLX3 Antibody

TLX3 Antibody

ArtNr	PRS-7375-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TLX3 Antibody: RNX, HOX11L2, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2
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Shipping	blue ice or RT
By Research Area	Stem Cell
Immunogen	TLX3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX3. The immunogen is located within the first 50 amino acids of TLX3.
Applications	TLX3 antibody can be used for detection of TLX3 by Western blot at 0.5 - 1 μ g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	TLX3 antibody is predicted to not cross-react with other TLX proteins.
Positive Control 1	Cat. No. 1306 - Human Spleen Tissue Lysate
Positive Control 2	Cat. No. 10-901 - Human Spleen Tissue Slide
Predicted Molecular Weight	Predicted: 32 kDa Observed: 30 kDa
Purification	TLX3 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	TLX3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Related Products	Cat. No. 7375P – TLX3 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TLX3
Accession #	NP_066305
Protein Gi #	50355978
Ncbi Gene Id #	30012
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	TLX3
Ncbi Official Full Name	T-cell leukemia homeobox 3
Ncbi Organism	homo sapiens
Swissprot #	O43711
Background	TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
Background References 1	Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Background References 2	Patterson KD and Kried PA. Hox11-family genes XHox11 and XHox11L2 in xenopus: XHoxL2 expression is restricted to a subset of the primary sensory neurons. Dev. Dyn. 1999; 214:34-43.
Background References 3	Cheng L, Arata A, Mizuguchi R, et al. Tlx3 and Tlx1 are post-mitotic selector genes determining the glutamatergic over GABAergic cell fates. Nat. Neurosci. 2004; 7:510-7.
Background References 4	Cheng L, Samad OA, Xu Y, et al. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat. Neurosci. 2005; 8:1510-5.
1st Image Caption	Western blot analysis of TLX3 in human spleen tissue lysate with TLX3 antibody at (A) 0.5 and (B) 1 μ g/mL.
2nd Image Caption	Immunohistochemistry of TLX3 in human spleen tissue with TLX3 antibody at 2.5 μ g/ml.
3rd Image Caption	Immunofluorescence of TLX3 in human spleen tissue with TLX3 antibody at 20 μ g/ml.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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