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KREMEN1 Antibody

KREMEN1 Antibody

ArtNr	PRS-7261-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	KREMEN1 Antibody: KRM1, KREMEN, KRM1, Kremen protein 1, Dickkopf receptor
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Shipping	blue ice or RT
By Research Area	Signal Transduction
Immunogen	Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1. The immunogen is located within the last 50 amino acids of KREMEN1.
Applications	KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 μ g/mL. Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	Three isoforms of KREMEN1 exists as a result of alternative splicing event.
Positive Control 1	Cat. No. 1468 - Rat Small Intestine Tissue Lysate
Positive Control 2	Cat. No. 11-801 - Human Small Intestine Tissue Slide
Predicted Molecular Weight	54 kDa
Purification	KREMEN1 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	KREMEN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Related Products	Cat. No. 7261P – KREMEN1 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	KREMEN1
Accession #	NP_114434
Protein Gi #	24041012
Ncbi Gene Id #	83999
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	KREMEN1
Ncbi Official Full Name	kringle containing transmembrane protein 1
Ncbi Organism	homo sapiens
Swissprot #	Q96MU8
Background	KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.
Background References 1	Nakamura T, Aoki S, Kitajima K, et al. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim. Biophys. Acta. 2001; 1518:63-72.
Background References 2	Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002; 417:664-7.
Background References 3	Li J, Liu WM, Cao YJ, et al. Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertil. Steril. 2008; 90:1470-9.
Background References 4	Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J. Biol. Chem. 2008; 283:23371-5.
1st Image Caption	Western blot analysis of KREMEN1 in rat small intestine tissue lysate with KREMEN1 antibody at (A) 0.125 and (B) 0.25 μ g/mL
2nd Image Caption	Immunohistochemistry of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 5 μ g/ml.
3rd Image Caption	Immunofluorescence of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 20 μ g/ml.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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