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VAMP7 Antibody

VAMP7 Antibody

ArtNr	PRS-6929-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Oncology Neuroscience Neural Signaling Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Bladder Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	VAMP7 Antibody: SYBL1, TIVAMP, VAMP-7, TI-VAMP, SYBL1, Vesicle-associated membrane protein 7, Synaptobrevin-like protein 1
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Shipping	blue ice or RT
By Research Area	Homeostasis
Homology	Predicted species reactivity based on immunogen sequence: Chicken: (100%), Bovine: (100%)
Immunogen	VAMP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human VAMP7. The immunogen is located within amino acids 20 - 70 of VAMP7.
Applications	VAMP7 antibody can be used for detection of VAMP7 by Western blot at 0.5 - 1 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	At least three isoforms of VAMP7 are known to exist; this antibody will detect the two longest isoforms. This antibody is predicted to not cross-react with other Ras-related proteins.
Positive Control 1	Cat. No. 1402 - Mouse Lung Tissue Lysate
Positive Control 2	Cat. No. 10-101 - Human Lung Tissue Slide
Predicted Molecular Weight	Predicted: 24, 29 kDa Observed: 32 kDa
Purification	VAMP7 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	VAMP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	VAMP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 6929P – VAMP7 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	VAMP7
Accession #	NP_001172112
Protein Gi #	297747292
Ncbi Gene Id #	6845
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	VAMP7
Ncbi Official Full Name	vesicle-associated membrane protein 7
Ncbi Organism	Homo sapiens
Swissprot #	P51809
Background	VAMP7 Antibody: VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
Background References 1	Galli T, Zahraoui A, Vaidyanathan VV, et al. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol. Biol. Cell 1998; 9:1437-48.
Background References 2	Wang Y and Tang BL. SNAREs in neurons - beyond synaptic vesicle exocytosis. Mol. Membr. Biol. 2006; 23:377-84.
Background References 3	Advani RJ, Yang B, Prekeris R, et al. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J. Cell Biol. 1999; 146:765-75.
Background References 4	Burgo A, Sotirakis E, Simmler MC, et al. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner in neurite growth. EMBO Rep. 2009; 10:1117-24.
1st Image Caption	Western blot analysis of VAMP7 in mouse lung tissue lysate with VAMP7 antibody at (A) 0.5 and (B) 1 μ g/mL.
3rd Image Caption	Immunofluorescence of VAMP7 in human lung tissue with VAMP7 antibody at 20 μ g/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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