Periphilin Antibody

blue ice or RT

Periphilin antibody was raised against a 16 amino acid synthetic peptide near the center of human Periphilin.

The immunogen is located within amino acids 160 - 210 of Periphilin.

Cat. No. 1411 - Mouse Colon Tissue Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 6687P – Periphilin Peptide

None

NP_958848

51535

PPHLN1

Homo sapiens

Periphilin Antibody: Periphilin, known as PPHLN1 or gastric cancer antigen Ga50, plays a role in epithelial differentiation and contributes to epidermal integrity and barrier formation. It interacts with periplakin, a known precursor of the cornified cell envelope. Periphilin 1 is ubiquitously expressed and localizes to nucleus and cytoplasm. Existing as eight alternatively spliced isoforms, Periphilin is highly insoluble and contains a putative nuclear localization signal (NLS) within its N-terminal half, a prerequisite for the formation of insoluble complexes and a possible caspase recognition sequence and a potential nuclear export signal. Periphilin may play an important role in the nervous system.

Kurita M, Suzuki H, Masai H, et al. Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest. Biochem. Biophys. Res. Commun. 2004; 324:554-61

Soehn AS, Franck T, Biskup S, et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics 2010; 11:203-15

Immunohistochemistry of Periphilin in human colon tissue with Periphilin antibody at 2.5 μ g/mL.