HIG2 Antibody

Cancer, Cell Cycle

HIG2 antibody can be used for detection of HIG2 by Western blot at 1 μ g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Cat. No. 1203 - A549 Cell Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 6491P – HIG2 Peptide

None

NP_001092256

192286

HIGD2A

Homo sapiens

HIG2 Antibody: HIG1 and HIG2 (Hypoxia-inducible gene 1 and 2, respectively) are known to be induced by hypoxic conditions. HIG2 is induced by hypoxia and by glucose deprivation in cultured cells. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Unlike HIG2, which is ubiquitously expressed and might be an activator and target of the canonical Wnt pathway, the function and the mechanisms underlying its regulation of HIG1 still remained unknown. The putative link between hypoxia and an oncogenic signaling pathway might play an important role in tumorigenesis.

Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep. 2000; 1:287-92

Gimm T, Wiese M, Teschemacher B, et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010; 24:4443-58.