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RASSF10 Antibody

RASSF10 Antibody

ArtNr	PRS-6371-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Oncology Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA, IHC-P
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	RASSF10 Antibody: Ras association domain-containing protein 10
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Shipping	blue ice or RT
By Research Area	Cancer, Cell Cycle
Immunogen	RASSF10 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human RASSF10. The immunogen is located within amino acids 50 - 100 of RASSF10.
Applications	RASSF10 antibody can be used for detection of RASSF10 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity	RASSF10 antibody will not cross-react with other RAS association domain-containing family members.
Positive Control 1	Cat. No. 1302 - Human Lung Tissue Lysate
Positive Control 2	Cat. No. 10-101 - Human Lung Tissue Slide
Purification	RASSF10 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	RASSF10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	RASSF10 antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 6371P – RASSF10 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	RASSF10
Accession #	NP_001073990
Protein Gi #	304434798
Ncbi Gene Id #	644943
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	RASSF10
Ncbi Official Full Name	Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
Ncbi Organism	Homo sapiens
Swissprot #	A6NK89
Background	RASSF10 Antibody: RASSF10 is a member of the N-terminal Ras association domain-containing family of proteins, a family of tumor suppressor genes that are frequently epigenetically inactivated in cancer. These proteins consist of RASSF7-10 and are structurally distinct from RASSF1-6, containing the N-terminal Ras association domain but lacking the Sav/RASSF/Hippo protein interaction domains. While little is known of the function of RASSF10, it is inactivated in both childhood leukemia and gliomas. In secondary glioblastomas, RASSF10 methylation can be used as an independent prognostic associated with worst progression-free survival and overall survival.
Background References 1	Sherwood V, Manbodh R, Sheppard C, et al. RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol. Biol. Cell 2008; 19:1772-82.
Background References 2	Hesson LB, Dunwell TL, Cooper WC, et al. The novel RASSF6 and RASSF10 candidate tumor suppressor genes are frequently epigenetically inactivated in childhood leukaemias. Mol. Cancer 2009; 8:42
Background References 3	Hill VK, Underhill-Day N, Krex D, et al. Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. Oncogene 2011; 30:30:978-89
1st Image Caption	Western blot analysis of RASSF10 in human lung tissue lysate with RASSF10 antibody at 1 μ g/mL
2nd Image Caption	Immunohistochemistry of RASSF10 in human lung tissue with RASSF10 antibody at 5 μ g/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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