ArtNr |
PRS-6053-0.1mg |
Hersteller |
ProSci
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, IF, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
SYNPO2L Antibody: Synaptopodin 2-like protein |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Signal Transduction |
Immunogen |
SYNPO2L antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SYNPO2L.
The immunogen is located within amino acids 140 - 190 of SYNPO2L. |
Applications |
SYNPO2L antibody can be used for detection of SYNPO2L by Western blot at 1 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. |
Positive Control 1 |
Cat. No. 1314 - Human Thymus Tissue Lysate |
Purification |
SYNPO2L Antibody is affinity chromatography purified via peptide column. |
Clonality |
Polyclonal |
Isotype |
IgG |
Conjugate |
Unconjugated |
Buffer |
SYNPO2L Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration |
1 mg/mL |
Storage Conditions |
SYNPO2L antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Related Products |
Cat. No. 6053P – SYNPO2L Peptide |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
SYNPO2L |
Accession # |
BAD37139 |
Protein Gi # |
51534920 |
Ncbi Gene Id # |
79933 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
SYNPO2L |
Ncbi Official Full Name |
synaptopodin 2-like |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q9H987 |
Background |
SYNPO2L Antibody: SYNPO2L was initially identified as a novel heart-enriched gene that encodes a cytoskeletal protein highly expressed in the Z-disc of heart and skeletal muscle, associates with actin and interacts with a-actinin. It is a member of the synaptopodin family, sharing greatest homology with Synaptopodin 2. Recent studies have shown that SYNPO2L, while primarily localized to the sarcomere, can also translocate to the nucleus. A knockdown of SYNPO2L in zebrafish resulted in aberrant cardiac and skeletal muscle development and function, suggesting that it is a critical component of the sarcomere and plays an important role in muscle development. |
Background References 1 |
Beqqali A, Kloots J, Ward-van Oostward D, et al. Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. Stem Cells2006; 24:1956-67. |
Background References 2 |
Beqqali A, Manshouwer-Kloots J, Moneiro R, et al. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. J. Cell Sci.2010; 123:1141-50. |
1st Image Caption |
Western blot analysis of SYNPO2L in human thymus tissue lysate with SYNPO2L antibody at 1 μ g/mL in (A) the absence and (B) the presence of blocking peptide. |
3rd Image Caption |
Immunofluorescence of SYNPO2L in mouse skeletal muscle tissue with SYNPO2L antibody at 20 μ g/mL. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.