ArtNr |
PRS-59-122-400ul |
Hersteller |
ProSci
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Major histocompatibility complex class I-related gene protein, MHC class I-related gene protein, Class I histocompatibility antigen-like protein, MR1 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Immunology |
Immunogen |
This MR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-341 amino acids from the C-terminal region of human MR1. |
Applications |
For WB starting dilution is: 1:1000 |
Predicted Molecular Weight |
39 kDa |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Clonality |
Polyclonal |
Isotype |
Rabbit Ig |
Conjugate |
Unconjugated |
Buffer |
Supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration |
batch dependent |
Storage Conditions |
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
MR1 |
Accession # |
Q95460 |
Protein Gi # |
74751679 |
Ncbi Gene Id # |
3140 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
MR1 |
Ncbi Official Full Name |
Major histocompatibility complex class I-related gene protein |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q95460 |
Background |
MR1 has antigen presentation function. Involved in the development and expansion of a small population of T cells expressing an invariant T cell receptor alpha chain called mucosal-associated invariant T cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therfore may be involed in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. |
Background References 1 |
Gozalbo-Lopez, B., et al. Histol. Histopathol. 24(11):1439-1449(2009) |
Background References 2 |
Stumpf, A.N., et al. Blood 114(17):3684-3692(2009) |
Background References 3 |
Huang, S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8290-8295(2009) |
Background References 4 |
Aldemir, H. Biochem. Biophys. Res. Commun. 366(2):328-334(2008) |
1st Image Caption |
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane). |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.