ArtNr |
PRS-57-440-400ul |
Hersteller |
ProSci
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB |
Specific against |
Human |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Proprotein convertase subtilisin/kexin type 7, 3421-, Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7, PCSK7, LPC, PC7, PC8, SPC7 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Cell Cycle |
Immunogen |
This PCSK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human PCSK7. |
Applications |
For WB starting dilution is: 1:1000 |
Predicted Molecular Weight |
86 kDa |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Clonality |
Polyclonal |
Isotype |
Rabbit Ig |
Conjugate |
Unconjugated |
Buffer |
Supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration |
batch dependent |
Storage Conditions |
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
PCSK7 |
Accession # |
Q16549 |
Protein Gi # |
205830663 |
Ncbi Gene Id # |
9159 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
PCSK7 |
Ncbi Official Full Name |
Proprotein convertase subtilisin/kexin type 7 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q16549 |
Background |
The protein encoded by this gene belongs to thesubtilisin-like proprotein convertase family. The members of thisfamily are proprotein convertases that process latent precursorproteins into their biologically active products. This encodedprotein is a calcium-dependent serine endoprotease. It isstructurally related to its family members, PACE and PACE4. Thisprotein is concentrated in the trans-Golgi network, associated withthe membranes, and is not secreted. It can process proalbumin andis thought to be responsible for the activation of HIV envelopeglycoproteins gp160 and gp140. This gene has been implicated in thetranscriptional regulation of housekeeping genes. Multiplealternatively spliced transcripts are described for this gene buttheir full length nature is not yet known. Downstream of thisgene's map location at 11q23-q24, nucleotides that match part ofthis gene's 3' end are duplicated and inverted. A translocationbreakpoint associated with lymphoma occurs between this gene andits inverted counterpart. |
Background References 1 |
Leonhardt, R.M., et al. J. Immunol. 184(6):2985-2998(2010) |
Background References 2 |
McColl, B.K., et al. FASEB J. 21(4):1088-1098(2007) |
Background References 3 |
Bruzzaniti, A., et al. Peptides 23(5):863-875(2002) |
Background References 4 |
Fugere, M., et al. J. Biol. Chem. 277(10):7648-7656(2002) |
1st Image Caption |
Western blot analysis in K562 cell line lysates (35ug/lane). |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.