HYAL2 Antibody

Cancer, Signal Transduction

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

This antibody is purified through a protein A column, followed by peptide affinity purification.

Rabbit Ig

Supplied in PBS with 0.09% (W/V) sodium azide.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

None

Q12891

8692

HYAL2

Homo sapiens

This gene encodes a weak acid-active hyaluronidase. Theencoded protein is similar in structure to other more activehyaluronidases. Hyaluronidases degrade hyaluronan, one of the majorglycosaminoglycans of the extracellular matrix. Hyaluronan andfragments of hyaluronan are thought to be involved in cellproliferation, migration and differentiation. Although it waspreviously thought to be a lysosomal hyaluronidase that is activeat a pH below 4, the encoded protein is likely a GPI-anchored cellsurface protein. This hyaluronidase serves as a receptor for theoncogenic virus Jaagsiekte sheep retrovirus. The gene is one ofseveral related genes in a region of chromosome 3p21.3 associatedwith tumor suppression. This gene encodes two alternatively splicedtranscript variants which differ only in the 5' UTR.

Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)

Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :

HYAL2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.