ArtNr |
PRS-55-646-400ul |
Hersteller |
ProSci
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, IHC-P |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Histone deacetylase 11, HD11, HDAC11 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Signal Transduction |
Immunogen |
This HDAC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11. |
Applications |
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 |
Predicted Molecular Weight |
39 kDa |
Purification |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis |
Clonality |
Polyclonal |
Isotype |
Rabbit Ig |
Conjugate |
Unconjugated |
Buffer |
Supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration |
batch dependent |
Storage Conditions |
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
HDAC11 |
Accession # |
Q96DB2 |
Protein Gi # |
26394832 |
Ncbi Gene Id # |
79885 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
HDAC11 |
Ncbi Official Full Name |
Histone deacetylase 11 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q96DB2 |
Background |
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor. |
Background References 1 |
Keedy, K.S. et al.Virol. May; 83(10): 4749?756(2009). |
Background References 2 |
Voelter-Mahlknecht S, et al., IntMol Med. 2005 Oct; 16(4):589-98. |
Background References 3 |
Bradbury CA, et al., Leukemia. 2005 Oct; 19(10):1751-9. |
Background References 4 |
Gregoretti IV, et al., Mol Biol. 2004 Apr 16; 338(1):17-31. |
1st Image Caption |
Antibody is used in Western blot to detect HDAC11 in mouse brain tissue lysate. |
2nd Image Caption |
Formalin-fixed and paraffin-embedded human testicle tumor tissue reacted with HDAC11 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.