HDAC11 Antibody

Signal Transduction

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Rabbit Ig

Supplied in PBS with 0.09% (W/V) sodium azide.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

None

Q96DB2

79885

HDAC11

Homo sapiens

HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.

Voelter-Mahlknecht S, et al., IntMol Med. 2005 Oct; 16(4):589-98.

Gregoretti IV, et al., Mol Biol. 2004 Apr 16; 338(1):17-31.

Formalin-fixed and paraffin-embedded human testicle tumor tissue reacted with HDAC11 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.