PALB2 Antibody

blue ice or RT

PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2.

The immunogen is located within amino acids 940 - 990 of PALB2.

At least four isoforms of PALB2 are known to exist; this antibody will detect all four isoforms.

Predicted: 65, 100, 130 kDa

Observed: 140 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 5275P – PALB2 Peptide

None

Q86YC2

79728

PALB2

Homo sapiens

PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.

Xia B, Sheng Q, Nakanishi K, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB. Mol. Cell 2007; 22:719-29.

Zhang F, Fan Q, Ren K, et al. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol. Cancer. Res. 2009; 7:1110-8.