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Stargazin Antibody

Stargazin Antibody

ArtNr	PRS-50-182-0.1mL
Hersteller	ProSci
Menge	0.1 mL
Kategorie	Neuroscience Neural Signaling Neural Epigenetics Antibodies Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Liquid
Applikationen	WB
Specific against	Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Shipping	blue ice or RT
Immunogen	Peptide corresponding to amino acid residues from the C-terminal region of rat stargazin, conjugated to keyhole limpet hemocyanin (KLH).
Applications	The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Predicted Molecular Weight	36
Purification	Affinity Purified
Clonality	Polyclonal
Conjugate	Unconjugated
Storage Conditions	Stargazin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Disclaimer	This product is for research use only.
Modifications	None
Ncbi Official Symbol	Cacng2
Accession #	O88602
Protein Gi #	6685280
Ncbi Gene Id #	12300
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	Cacng2
Ncbi Official Full Name	calcium channel, voltage-dependent, gamma subunit 2
Ncbi Organism	Mus musculus
Swissprot #	O88602
Background	Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002).
Background References 1	Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS, (2005) Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435: 1052-1058.
Background References 2	Priel A, Kolleker A, Ayalon G, Gillor M, Osten P, Stern-Bach Y. (2005) Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J. Neurosci. 25, 2682–2686.
Background References 3	Choi, J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E, Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.J Biol Chem. 2002 Apr 5; 277(14):12359-63.
1st Image Caption	Western blot of rat synaptic membrane (SPM) showing specific immunolabeling of the ~ 36k stargazin protein.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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