Retinoic Acid Receptor Antibody [763]

Peptide corresponding to amino acid residues from the N-terminal region of human retinoic acid receptor, a-isotype.

48

Monoclonal

IgG1

Retinoic Acid Receptor antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

None

P10276

5914

RARA

Homo sapiens

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRalpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.

Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RAR-alpha protein.