IL-16 Antibody

blue ice or RT

IL-16 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human IL-16.

The immunogen is located within amino acids 140 - 190 of IL-16.

This antibody will only detect the NIL-16 isoform.

Predicted: 145 kDa

Observed: 160 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 4995P – IL-16 Peptide

None

AAQ86961

3603

IL16

Homo sapiens

IL-16 Antibody: IL-16 was initially identified as a chemotactic cytokine, but is now known to possess a wide range of activities. Later studies have more fully characterized IL-16 as an immunomodulatory cytokine that contributes to the regulatory process of CD4+ T cell recruitment and activation at sites of inflammation in association with asthma and several autoimmune diseases. The precursor of IL-16 (pro-IL-16) is thought to be cleaved towards the C-terminal region by Caspase-3, releasing a 20 kDa active form that binds to and signals through CD4. Besides acting as a chemotactic cytokine, IL-16 is thought to also be involved in the regulation of T cell proliferation and multiple infectious, immune-mediated, and autoimmune inflammatory disorders including irritable bowel syndrome, systemic lupus erythematosus, and neurodegenerative disorders. At least two isoforms of IL-16 are known to exist; the longer isoform (also known as NIL-16) is detected only in neurons of the cerebellum and hippocampus.

Interleukin-16. Cruikshank WW, Kornfeld H, and Center DM. J. Leukoc. Biol.2000; 67:757-66.

Maciaszek JW, Parada NA, Cruikshank WW, et al. IL-16 represses HIV-1 promoter activity. J. Immunol.1997; 158:5-8.

Immunohistochemistry of IL-16 in mouse brain tissue with IL-16 antibody at 2.5 μ g/mL.