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PTCHD2 Antibody

PTCHD2 Antibody

ArtNr	PRS-4925-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry ELISA Primary Antibodies By Organ Thyroid Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	ELISA, IHC-P
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	PTCHD2 Antibody: DISP3, DISP3, KIAA1337, Patched domain-containing protein 2, Protein dispatched homolog 3
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Shipping	blue ice or RT
By Research Area	Signal Transduction
Immunogen	PTCHD2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human PTCHD2. The immunogen is located within amino acids 210 - 260 of PTCHD2.
Applications	PTCHD2 antibody can be used for detection of PTCHD2 by immunohistochemistry at 5 μ g/mL. Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity	At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins.
Positive Control 1	Cat. No. 10-701 - Human Testis Tissue Slide
Purification	PTCHD2 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	PTCHD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 4925P – PTCHD2 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	PTCHD2
Accession #	Q9P2K9
Protein Gi #	149274653
Ncbi Gene Id #	57540
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	PTCHD2
Ncbi Official Full Name	patched domain containing 2
Ncbi Organism	Homo sapiens
Swissprot #	Q9P2K9
Background	PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.
Background References 1	Katoh Y and Katoh M. Identification and characterization of DISP3 gene in silico. Int. J. Oncol. 2005; 26:551-6
Background References 2	Katoh Y and Katoh M. Hedgehog signaling pathway and gastric cancer. Can. Biol. & Ther. 2005; 4:1050-4
Background References 3	Zikova M, Corlett A, Bendova Z, et al. DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism. Mol. Endocrin. 2009; 23:520-8.
1st Image Caption	Immunohistochemistry of PTCHD2 in human testis tissue with PTCHD2 antibody at 5 μ g/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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Lieferung vsl. bis 06.09.2024

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