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GSTP1 Antibody

GSTP1 Antibody

ArtNr	PRS-4413-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GSTP1 Antibody: PI, DFN7, GST3, GSTP, FAEES3, HEL-S-22, Glutathione S-transferase P, GST class-pi
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Shipping	blue ice or RT
By Research Area	Homeostasis
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (93%), Goat: (86%), Pig: (85%)
Immunogen	GSTP1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human GSTP1. The immunogen is located within amino acids 90 - 140 of GSTP1.
Applications	GSTP1 antibody can be used for the detection of ATG10 by Western blot at 0.5 - 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1	Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 2	Cat. No. 10-101 - Human Lung Tissue Slide
Purification	GSTP1 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	GSTP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	GSTP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 4413P – GSTP1 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	GSTP1
Accession #	NP_000843
Protein Gi #	4504183
Ncbi Gene Id #	2950
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	GSTP1
Ncbi Official Full Name	glutathione S-transferase pi 1
Ncbi Organism	Homo sapiens
Swissprot #	P09211
Background	GSTP1 Antibody: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism (i.e., the metabolism of environmental mutagens and carcinogens) and may play a role in susceptibility to cancer. More recent experiments have suggested that differential expression of GSTP1 also contributes to the sensitivity of xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders such as Parkinson's disease. CpG island hypermethylation of the GSTP1 promoter leading to the silencing of the GSTP1 gene has also been linked to cancer.
Background References 1	Pearson WR. Phylogenies of glutathione transferase families. Methods Enzymol.2005; 401:186-204.
Background References 2	Clapper ML. Genetic polymorphism and cancer risk. Curr. Oncol. Rep.2000; 2:251-6.
Background References 3	Smeyne M, Boyd J, Shepherd KR, etc. GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Proc. Natl. Acad. Sci. USA2007; 104:1977-82.
Background References 4	Ellinger J, Bastian PJ, Jurgan T, et al. CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. Urology2008; 71:161-7.
1st Image Caption	Western blot analysis of GSTP1 in Jurkat cell lysate with GSTP1 antibody at (A) 0.5 and (B) 1 μ g/mL.
2nd Image Caption	Immunohistochemical staining of human lung tissue using GSTP1 antibody at 2.5 μ g/mL.
3rd Image Caption	Immunofluorescence of GSTP1 in Human Lung cells with GSTP1 antibody at 20 μ g/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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