KIF5 Antibody

Neuroscience

KIF5 antibody can be used for detection of KIF5 by Western blot at 0.5 - 1 μ g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Cat. No. 1204 - K562 Cell Lysate

Predicted: 105, 114 kDa

Observed: 118 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 4291P – KIF5 Peptide

None

Q12840

3798

KIF5A

Homo sapiens

KIF5 Antibody: The kinesin superfamily proteins (KIFs) are microtubule-dependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. Mutations in one of the three isoforms of KIF5 (KIF5A) are thought to be involved in hereditary spastic paraplegias.

Niclas J, Navone F, Hom-Booher N, et al. Cloning and localization of a conventional KIF5 motor expressed exclusively in neurons. Neuron 1994; 12:1059-72.

Western blot analysis of KIF5 in K562 cell lysate with KIF5 antibody at (A) 0.5 and (B) 1 μ g/mL.

Immunofluorescence of KIF5 in K562 cells with KIF5 antibody at 20 μ g/mL.