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FEZ1 Antibody

FEZ1 Antibody

ArtNr	PRS-4265-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FEZ1 Antibody: Fasciculation and elongation protein zeta-1, Zygin I
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Shipping	blue ice or RT
By Research Area	Neuroscience
Immunogen	FEZ1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FEZ1. The immunogen is located within amino acids 270 - 320 of FEZ1.
Applications	FEZ1 antibody can be used for the detection of FEZ1 by Western blot at 0.5 - 1 μ g/mL. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1	Cat. No. 1207 - Raji Cell Lysate
Predicted Molecular Weight	Predicted: 42 kDa Observed: 46 kDa
Purification	FEZ1 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	FEZ1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	FEZ1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 4265P – FEZ1 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	FEZ1
Accession #	Q99689
Protein Gi #	13431526
Ncbi Gene Id #	9638
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	FEZ1
Ncbi Official Full Name	fasciculation and elongation protein zeta 1 (zygin I)
Ncbi Organism	Homo sapiens
Swissprot #	Q99689
Background	FEZ1 Antibody: Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist.
Background References 1	Kuroda S, Nakagawa N, Tokunaga C, et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C z-interacting protein. J. Cell Biol.1999; 144:403-11.
Background References 2	Bloom L and Horvitz HR. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc. Natl. Acad. Sci. USA1997; 88:9578-82.
Background References 3	Miyohi K, Honda A, Baba K, et al. Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry2003; 8:685-94.
Background References 4	Blasius TL, Cai D, Jih GT, et al. Two binding partners cooperate to activate the molecular motor kinesin-1. J. Cell Biol.2007; 176:11-7.
1st Image Caption	Western blot analysis of SAPAP2 in Raji cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 μ g/mL.

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Menge: 0.02 mg

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