HAP1 Antibody

blue ice or RT

HAP1 antibody was raised against a 19 amino acid synthetic peptide from near the center of human HAP1.

The immunogen is located within amino acids 310 - 360 of HAP1.

Cat. No. 1403 - Mouse Brain Tissue Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 4205P – HAP1 Peptide

None

CAC09418

9001

HAP1

Homo sapiens

HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

Li X-J, L S-H, Sharp AH, et al. A huntingtin-associated protein enriched in brain with implications for pathology. Nature1995; 378:398-402.

Gauthier LR, Charrin BC, Borrell-Pages M, et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell2004; 118:127-38.

Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 μ g/mL.