TRPC6 Antibody

blue ice or RT

TRPC6 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TRPC6.

The immunogen is located within amino acids 50 - 100 of TRPC6.

This antibody may cross-react with TRPC3.

Cat. No. 1402 - Mouse Lung Tissue Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 3899P – TRPC6 Peptide

None

AAH93658

7225

TRPC6

Homo sapiens

TRPC6 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.

Dietrich A, Kalwa H, Rost BR, et al. The diacylglycerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005; 451:72-80.

Western blot analysis of TRPC6 in K562 cell lysate with TRPC6 antibody at (A) 0.5 and (B) 1 μ g/mL.

Immunocystochemistry of TRPC6 in K562 cells with TRPC6 antibody at 2 μ g/mL.