DDX3 Antibody

blue ice or RT

DDX3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human DDX3.

The immunogen is located within amino acids 110 - 160 of DDX3.

DDX3 antibody will detect both DDX3 and DBY.

Cat. No. 17-011 - Hep G2 Cell Slide

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 3757P – DDX3 Peptide

None

AAC34298

1654

DDX3X

Homo sapiens

DDX3 Antibody: DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases. DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome. DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation. It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.

Park SH, Lee SG, Kim Y, et al. Assignment of a human putative RNA helicase gene, DDX3, to human X chromosome bands p11.3-->p11.23. Cytogenet. Cell Genet. 1998; 81:178-9.

Abdelhaleem M. RNA helicases: regulators of differentiation. Clin. Biochem. 2005; 38:499-503.

Immunocytochemistry of DDX3 in HepG2 cells with DDX3 antibody at 10 μ g/mL.