ArtNr |
PRS-3651-0.02mg |
Hersteller |
ProSci
|
Menge |
0.02 mg |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, ICC, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
TLR6 Antibody: CD286, Toll-like receptor 6 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Signal Transduction |
Immunogen |
TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6.
The immunogen is located within amino acids 160 - 210 of TLR6. |
Applications |
TLR6 antibody can be used for detection of TLR6 by Western blot at 1 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. |
Specificity |
This TLR6 antibody is predicted to have no cross-reactivity to other members of the TLR protein family. |
Positive Control 1 |
Cat. No. 1224 - Daudi Cell Lysate |
Positive Control 2 |
Cat. No. 17-005 - Jurkat Cell Slide |
Predicted Molecular Weight |
Observed: 91 kDa |
Purification |
TLR6 Antibody is affinity chromatography purified via peptide column. |
Clonality |
Polyclonal |
Isotype |
IgG |
Conjugate |
Unconjugated |
Buffer |
TLR6 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration |
1 mg/mL |
Storage Conditions |
TLR6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Related Products |
Cat. No. 3651P – TLR6 Peptide |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
TLR6 |
Accession # |
NP_006059 |
Protein Gi # |
20143971 |
Ncbi Gene Id # |
10333 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
TLR6 |
Ncbi Official Full Name |
toll-like receptor 6 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q9Y2C9 |
Background |
TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses. |
Background References 1 |
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76. |
Background References 2 |
Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216. |
Background References 3 |
McGettrick AF and O’Neill LAJ. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Imm. 2004; 41:577-82. |
Background References 4 |
Takeuchi O, Kawai T, Sanjo H, et al. TLR6: A novel member of an expanding Toll-like receptor family. Gene 1999; 231:59-65. |
1st Image Caption |
Western blot analysis of TLR6 in Daudi cell lysate with TLR6 antibody at 1 μ g/mL in (A) the absence and (B) the presence of blocking peptide. |
2nd Image Caption |
Immunocytochemistry of TLR6 in Jurkat cells with TLR6 antibody at 10 μ g/mL. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.