ArtNr |
PRS-27-668-100ul |
Hersteller |
ProSci
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, ELISA |
Specific against |
Human, Mouse, Rat, Canine |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
PTK2B, PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Cancer , Signal Transduction , Apoptosis |
Immunogen |
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PTK2B. |
Applications |
PTK2B antibody can be used for detection of PTK2B by ELISA at 1:312500. PTK2B antibody can be used for detection of PTK2B by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50, 000 - 100, 000. |
Positive Control 1 |
Cat. No. 1211 - HepG2 Cell Lysate |
Predicted Molecular Weight |
116 kDa |
Purification |
Antibody is purified by peptide affinity chromatography method. |
Clonality |
Polyclonal |
Conjugate |
Unconjugated |
Buffer |
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Concentration |
batch dependent |
Storage Conditions |
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PTK2B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles. |
Disclaimer |
This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
PTK2B |
Accession # |
NP_004094 |
Protein Gi # |
27886584 |
Ncbi Gene Id # |
2185 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
PTK2B |
Ncbi Official Full Name |
protein tyrosine kinase 2 beta |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q14289 |
Background |
PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. |
Background References 1 |
Ling, S., et al., (2004) Am. J. Physiol., Cell Physiol. 287 (3), C698-C706. |
1st Image Caption |
Antibody used in WB on Human HepG2 at 0.2-1 ug/ml. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.