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Caspase-14 Antibody

Caspase-14 Antibody

ArtNr	PRS-2509-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Neuroscience Neuroinflammation Neural Signaling Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caspase-14 Antibody: MICE, mini-ICE, Caspase-14, Mini-ICE, CASP-14
Lieferbar
Shipping	blue ice or RT
By Research Area	Apoptosis
Immunogen	Caspase-14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human caspase-14. The immunogen is located within the last 50 amino acids of Caspase-14.
Applications	Caspase-14 antibody can be used for the detection of caspase-14 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ g/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Positive Control 1	Cat. No. 1205 - Jurkat Cell Lysate
Positive Control 2	Cat. No. 1304 - Human Liver Tissue Lysate
Positive Control 3	Cat. No. 10-201 - Human Liver Tissue Slide
Predicted Molecular Weight	Predicted: 28 kDa Observed: 27 kDa
Purification	Caspase-14 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	Caspase-14 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	Caspase-14 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 2509P – Caspase-14 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	Casp14
Accession #	ACA63845
Protein Gi #	169666460
Ncbi Gene Id #	23581
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	Casp14
Ncbi Official Full Name	caspase 14
Ncbi Organism	Homo sapiens
Swissprot #	P31944
Background	Caspase-14 Antibody: Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Caspase-14 is highly expressed in embryonic but not adult tissues. It is processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in the keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
Background References 1	Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
Background References 2	Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.
Background References 3	Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995; 267:2000-3.
Background References 4	Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.
1st Image Caption	Western blot analysis of caspase-14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with caspase-14 antibody at 1 μ g/mL.
2nd Image Caption	Immunohistochemistry of caspase-14 in human liver tissue with caspase-14 antibody at 2.5 μ g/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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