MTBP Antibody

Apoptosis, Cancer

MTBP antibody was raised against a 18 amino acid peptide near the center of human MTBP.

The immunogen is located within amino acids 110 - 160 of MTBP.

Cat. No. 1204 - K562 Cell Lysate

Predicted: 104 kDa

Observed: 104 kDa

Polyclonal

Unconjugated

1 mg/ml

Cat. No. 2447P – MTBP Peptide

None

NP_071328

27085

MTBP

Homo sapiens

MTBP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature. 2000; 404:42-9.

Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell. 2000 Sep 15; 102(6):849-62.

Immunocytochemistry of MTBP in K562 cells with MTBP antibody at 5 μ g/mL.