IDH2 Antibody

blue ice or RT

Recombinant fusion protein containing a sequence corresponding to amino acids 193-452 of human IDH2 (NP_002159.2).

HL-60

Jurkat

U-87MG

Observed: 51kDa

Polyclonal

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

3418

IDH2

Homo sapiens

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.

Immunohistochemistry of paraffin-embedded human colon carcinoma using IDH2 antibody (22-769) at dilution of 1:100 (40x lens).

Immunoprecipitation analysis of 200ug extracts of MCF7 cells using 1ug IDH2 antibody (22-769). Western blot was performed from the immunoprecipitate using IDH2 antibody (22-769) at a dilition of 1:1000.