DR6 Antibody

Apoptosis

DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6.

The immunogen is located within amino acids 30 - 80 of DR6.

Cat. No. 1201 - HeLa Cell Lysate

68 kDa

Polyclonal

Unconjugated

1 mg/ml

Cat. No. 2157P – DR6 Peptide

None

AF068868

27242

TNFRSF21

Homo sapiens

DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κ B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

Western blot analysis of DR6 in K562 (1, 3) and Raji (2, 4) whole cell lysate in the absence (1, 2) or presence (3, 4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.