TCEB2 Antibody

blue ice or RT

Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human TCEB2 (NP_009039.1).

Observed: 18kDa

Polyclonal

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

6923

TCEB2

Homo sapiens

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.

Immunoprecipitation analysis of 150ug extracts of MCF7 cells using 3ug TCEB2 antibody (19-616). Western blot was performed from the immunoprecipitate using TCEB2 antibody (19-616) at a dilition of 1:500.