ArtNr |
PRS-15-407-100uL |
Hersteller |
ProSci
|
Menge |
100 uL |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Liquid |
Applikationen |
WB, FC |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
KCNJ11, potassium inwardly-rectifying channel, subfamily J, member 11, BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3, ATP-sensitive inward rectifier potassium channel 11, beta-cell inward rectifier subunit, inwardly rectifying potassium channel KIR6.2, |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Cancer, Neuroscience, Signal Transduction |
Immunogen |
A synthetic peptide of human KCNJ11 |
Applications |
WB: 1:500 - 1:2000
Flow: 1:20 - 1:50 |
Positive Control 1 |
Mouse heart |
Predicted Molecular Weight |
Observed: 44kDa |
Purification |
Affinity purification |
Clonality |
Polyclonal |
Isotype |
IgG |
Conjugate |
Unconjugated |
Buffer |
PBS with 0.02% sodium azide, pH7.3. |
Storage Conditions |
Store at 4˚ C. Avoid freeze / thaw cycles. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
KCNJ11 |
Ncbi Gene Id # |
3767 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
KCNJ11 |
Ncbi Official Full Name |
potassium inwardly-rectifying channel, subfamily J, member 11 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q14654 |
Background |
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. |
1st Image Caption |
Western blot analysis of extracts of mouse heart, using KCNJ11 antibody (15-407). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.