BMI1 Antibody

Cell Cycle

WB: 1:500 - 1:2000

IP: 1:50 - 1:100

K-562

Observed: 42kDa

Polyclonal

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

648

BMI1

Homo sapiens

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Immunoprecipitation analysis of 200ug extracts of K-562 cells, using 3 ug BMI1 antibody (13-080). Western blot was performed from the immunoprecipitate using BMI1 antibody (13-080) at a dilition of 1:1000.