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DR3 Antibody

DR3 Antibody

ArtNr	PRS-1120-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Antibodies Western Blot ELISA Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DR3 Antibody: DR3, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12, APO3, DR3, WSL, WSL1, UNQ455/PRO779, Tumor necrosis factor receptor superfamily member 25, Apo-3
Lieferbar
Shipping	blue ice or RT
By Research Area	Apoptosis
Immunogen	DR3 antibody was raised against a 20 amino acid peptide near the carboxy terminus of human DR3. The immunogen is located within the last 50 amino acids of DR3.
Applications	DR3 antibody can be used for Western blot 0.5 μ g/mL. A 59 kDa band should be detected. Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity	No cross reaction to other death receptors.
Positive Control 1	Cat. No. 1205 - Jurkat Cell Lysate
Predicted Molecular Weight	59 kDa
Purification	DR3 Antibody is Antibody is DEAE purified.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	DR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Storage Conditions	DR3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 1120P – DR3 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TNFRSF25
Accession #	AAQ88676
Protein Gi #	37181738
Ncbi Gene Id #	8718
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	TNFRSF25
Ncbi Official Full Name	tumor necrosis factor receptor superfamily, member 25
Ncbi Organism	Homo sapiens
Swissprot #	Q93038
Background	DR3 Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κ B activation.
Background References 1	Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996; 274:990-
Background References 2	Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996; 384:372-5.
Background References 3	Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996; 6:1669-76.
Background References 4	Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997; 6:79-88.
1st Image Caption	Western blot analysis of DR3 in Jurkat total cell lysate with DR3 antibody at 1:500 dilution.
2nd Image Caption	Immunofluorescence of DR3 in Jurkat cells with DR3 antibody at 20 μ g/mL. Green: DR3 Antibody (1120) Blue: DAPI staining

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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Lieferung vsl. bis 06.09.2024

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