Hersteller |
NKMAX
|
Kategorie |
|
Typ |
Antibody Monoclonal |
Specific against |
Human |
Clon |
2C5 |
Isotype |
IgG1 kappa |
Applikationen |
WB, IF, ICC, ELISA |
Menge |
100ul |
Host |
Mouse |
ArtNr |
NKM-ATGA0583-100ul |
Konjugat/Tag |
Unconjugated |
eClass 6.1 |
32160702 |
eClass 9.0 |
42030590 |
Lieferbar |
|
Alias |
ACAT1, |
Ab Purification Comment |
By protein-A affinity chromatography |
Additional Comment Only |
This product was produced from tissue culture supe |
Antigen Species |
Human |
Concentration |
1mg/ml (determined by BCA assay) |
Description |
ACAT1 (acetyl-Coenzyme A acetyltransferase 1) is a 417 amino acid protein. ACAT1 is a mitochondrial enzyme involved in the formation and degradation of ketone bodies and is necessary for the proper metabolic processing of isoleucine. ACAT1 and ACAT2 catalyze the formation of acetoacetyl-CoA from two acetyl-CoA molecules. These enzymes are also capable of the reverse reaction. Defects in ACAT1 are a cause of 3-ketothiolase deficiency. 3-ketothiolase deficiency is an inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. |
Formulation |
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol |
Gene Category |
Cancer |
General References |
Antonenkov, V.D., et al. (2000) Eur J Biochem 267: 2981-2990.; ; Korman, S.H. (2006) Mol Genet Metab 89: 289-299.; ; Yamaguchi, S., et al. (1988) J Clin Invest 81(3): 813-817. |
Immunogen |
Recombinant human ACAT1 (34-427aa) purified from E. coli |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Usage |
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. |
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