ArtNr |
MB9542-100 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, FC, IHC, ICC |
Specific against |
Human |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
HAVcr-2, TIMD-3, TIM-3, HAVCR2, TIM3, TIMD3, CD366, FLJ14428, HAVcr-2, Havcr2, HAVR2, Hepatitis A virus cellular receptor 2, Kidney injury molecule 3, KIM 3, KIM3, T cell immunoglobulin and mucin domain containing 3, T cell immunoglobulin mucin 3, T-cell |
Lieferbar |
|
Swiss-Prot |
Q8TDQ0(Human) |
Application_all |
WB:1:500-1:2, 000 ICC:1:50-1:200 IHC:1:100-1:200 FC:1:50-1:100 |
Background |
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse. |
Product |
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification And Purity |
ProA affinity purified |
Storage And Stability |
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles. |
Specificity |
Tim3 monoclonal antibody detects endogenous levels of Tim3 protein. |
BiowMW |
33 kDa (Predicted band size) |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Recombinant protein |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.