Anti-Mouse Survivin (CT)

Antibody Details

Product Details

Reactivity Species

Mouse

Host Species

Rabbit

Immunogen

PN:S494

Product Concentration

0.5 mg/ml

Formulation

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Storage and Handling

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Country of Origin

USA

Shipping

Next Day Ambient

RRID

AB_2831762

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Anti-Mouse Survivin recognizes an epitope near the C-terminus of Mouse Survivin. This polyclonal antibody was purified using affinity chromatography.

Background

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP.^1-3 Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.^{1, 3}

Antigen Details

Protein

Survivin

PubMed

Survivin

References & Citations

1. Ambrosini, G. et al. (1997) Nat. Med. 3:917
2. Li, F. et al. (1998) Nature 396:580
3. Kobayashi, K. et al. (1999) Proc. Natl. Acad. Sci. USA 96:1457

Technical Protocols