Anti-Human IL-27 (NT)

Antibody Details

Product Details

Reactivity Species

Human

Host Species

Rabbit

Immunogen

PN:I-513

Product Concentration

1.0 mg/ml

Formulation

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Storage and Handling

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Country of Origin

USA

Shipping

Next Day Ambient

RRID

AB_2830712

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Anti-Human Interleukin-27 (IL-27) recognizes an epitope near the N-terminus of Human and Mouse IL-27. This polyclonal antibody was purified using affinity chromatography.

Background

Interleukin-27 (IL-27) is a novel IL-12 family member that plays a role in the early regulation of T helper cell 1 initiation, including induction of T-bet and IL-12 receptor beta 2 expression.¹ IL-27 is produced by antigen-presenting cells² and plays an important function in regulating the activity of B and T lymphocytes.3 IL27 may be a potential therapeutic agent against rheumatoid arthritis (RA) at the onset of the disease.⁴

Antigen Details

Protein

IL-27

PubMed

IL-27

References & Citations

1. Yoshimoto T et al. (2004) Cancer Res. 64: 1152
2. De Sauvage FJ et al. (2003) Proceedings of the National Acad of Sci of USA 100: 15047
3. Devergne O et al. (2006) J Immunol. 176: 5890
4. Liew FY et al. (2008) Ann Rheum Dis. 67: 1474

Technical Protocols