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Denosumab Biosimilar - Research Grade

Denosumab Biosimilar - Research Grade

ArtNr	ICH4019-10MG
Hersteller	IchorBio
Menge	10 mg
Quantity options	100 mg 10 mg 1 mg 20 mg 50 mg 5 mg
Kategorie	Antibodies In Vivo Antibodies
Typ	Biosimilars
Specific against	Human (Homo sapiens)
Host	Humanized
Isotype	IgG
Purity	>95% by SDS-PAGE and HPLC
Citations	RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model Narsimhan et al. Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies. Analytical Chemistry
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254, Rank Ligang
Versandbedingung	Gekühlt
Lieferbar
Specificity	Detects human RANK Ligand. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Denosumab. This product is for research use only.
Manufacturer - Category	Low endotoxin, Biosimilar, recombinant antibody
Manufacturer - Isotype	Human IgG2
Manufacturer - Targets	RANKL
Manufacturer - Host	Humanized
Shipping Temperature	Blue ice
Storage Conditions	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation	Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background	Denosumab biosimilar is a human IgG2 monoclonal antibody that binds to human RANKL. Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Detects human RANK Ligand. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Denosumab.
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control	Bulk Human IgG2 Isotype Control (IB2) [ICH2255]
Buffer	ICH3001-100ml ICH3002-100ml ICH3003-100ml

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Einfache Bestellung Periodische Bestellung

Menge: 10 mg

lieferbar

Lieferung vsl. bis 07.02.2025

Express-Lieferung: 18 Tage sparen

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