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Alemtuzumab Biosimilar - Research Grade Europäischer Partner

ArtNr ICH4002-5MG
Hersteller IchorBio
Menge 5 mg
Quantity options 100 mg 10 mg 1 mg 20 mg 50 mg 5 mg
Kategorie
Typ Biosimilars
Specific against Human (Homo sapiens)
Host Humanized
Isotype IgG1 Kappa
Purity >95% by SDS-PAGE and HPLC
Citations Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression
Gravina et al. Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity. Cell Stem Cell 30, 1538–1548
Iadonato et al. A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors. Front Immunol. 2023; 14: 1311658.
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Campath-1 antigen, Cambridge pathology 1 antigen, HE5
Versandbedingung Gekühlt
Lieferbar
Specificity Detects human CD52. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Alemtuzumab. This product is for research use only.
Manufacturer - Category
Low endotoxin, Biosimilar, recombinant antibody
Manufacturer - Isotype
Human IgG1 Kappa
Manufacturer - Targets
CD52
Manufacturer - Host
Humanized
Shipping Temperature
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background
Alemtuzumab biosimilar is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) directed against the 21-28 kD cell surface glycoprotein, CD52, is an IgG1 kappa antibody with human variable framework and constant regions, and complementarity-determining regions from a murine (rat) monoclonal antibody. The alemtuzumab biosimilar has an approximate molecular weight of 150 kD and is produced in mammalian cell (Chinese hamster ovary) suspension culture in a medium.
Concentration
1.0 - 5.0 mg/ml
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity
Detects human CD52. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Alemtuzumab.
Purification method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control
Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
Buffer
ICH3001-100ml
ICH3002-100ml
ICH3003-100ml

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 5 mg
Lieferbar: In stock
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