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Anti-Mouse CTLA-4 In Vivo Antibody - Ultra Low Endotoxin (UC10-4F10-11)

Anti-Mouse CTLA-4 In Vivo Antibody - Ultra Low Endotoxin (UC10-4F10-11)

ArtNr	ICH1085UL-25MG
Hersteller	IchorBio
Menge	25mg
Kategorie	Antibodies In Vivo Antibodies
Typ	Antibody
Applikationen	WB, FC, IP, FA
Clon	UC10-4F10-11
Specific against	Mouse
Host	Hamster - Armenian
Isotype	IgG
Purity	>98% by SDS-PAGE and HPLC
ECLASS 5.1	32160702
ECLASS 6.1	32160702
ECLASS 8.0	32160702
ECLASS 9.0	32160702
ECLASS 10.0.1	32160702
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ctla4, Cytotoxic T-lymphocyte protein 4, CD152
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Specificity	Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152
Manufacturers Product Category	Ultra-Low Endotoxin, anti-mouse
Target Information	CTLA-4
Isotype Information	Armenian Hamster IgG1 Kappa
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution	The UC10-4F10-11 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.
Background	CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
Immunogen	Purified Recombinant Mouse CTLA4 Fc Fusion Protein
Concentration	≥ 2.0 mg/ml
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.4, without BSA or sodium azide added.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Aggregation	Aggregation level ≤ 1%
IMPACT Pathogen Test	We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our hamster antibodies are tested for: - Mycoplasma spp - Mycoplasma pulmonis - Pneumonia virus of mice - Kilham's rat virus - Toolan's H1 virus - Hamster parvovirus - Lymphocytic choriomeningitis - Minute virus of mice - Theiler's murine encephalomyelitis virus - Sendai virus - Reovirus 3 - Hantaan virus
Storage	anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.
Application Notes	Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. - Each investigator should determine their own optimal working dilution for specific applications.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 25mg

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Lieferung vsl. bis 16.08.2024

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