Anti-CTLA-4 (9H10) In Vivo Antibody - Low Endotoxin

Western Blot, Blocking, ELISA, Flow Cytometry

Syrian Hamster IgG

Blue ice

Aggregation level ≤ 5%

Activated T cells

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. Clone 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA4 binding, allowing for CD28 binding.

≤ 1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

Mouse CTLA-4-human IgG1 fusion protein

ICH1085-1MG, ICH1096-1MG, ICH1085-1MG