ArtNr |
FNab09540-100ug |
Hersteller |
FineTest
|
Menge |
100ug |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
liquid |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
API3, BIRC4, hIAP 3, hIAP3, hILP, IAP 3, IAP like protein, IAP3, ILP, ILP1, MIHA, X linked IAP, XIAP, XLP2 |
Lieferbar |
|
Purification |
Immunogen affinity purified |
Purity |
>=95% as determined by SDS-PAGE |
Clonality |
polyclonal |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20C for 12 months (Avoid repeated freeze / thaw cycles.) |
Background |
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti- apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11. |
Immunogen |
X-linked inhibitor of apoptosis |
Observed MW |
54 kDa |
Uniprot ID |
P98170 |
Tested Application |
ELISA, WB, IHC, IF |
Recommended dilution |
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:100 |
Gene ID |
331 |
Research Area |
Epigenetics, Cancer, Metabolism |
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