ArtNr |
FNab00388-100ug |
Hersteller |
FineTest
|
Menge |
100ug |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
liquid |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM |
Lieferbar |
|
Purification |
Immunogen affinity purified |
Purity |
>=95% as determined by SDS-PAGE |
Clonality |
polyclonal |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20C for 12 months (Avoid repeated freeze / thaw cycles.) |
Background |
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy' s disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. |
Immunogen |
androgen receptor |
Observed MW |
100 kDa |
Uniprot ID |
P10275 |
Tested Application |
ELISA, WB, IHC |
Recommended dilution |
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
Gene ID |
367 |
Research Area |
Signal Transduction, Metabolism, Cancer, Immunology, Neuroscience |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.