ArtNr |
CSB-PA889093LA01HU-50ug |
Hersteller |
Cusabio
|
Menge |
50ug |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, IF, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
C1orf136 antibody; DISC1 antibody; DISC1_HUMAN antibody; Disrupted in schizophrenia 1 antibody; Disrupted in schizophrenia 1 protein antibody; KIAA0457 antibody; RP4-730B13.1 antibody; SCZD9 antibody, Disrupted in schizophrenia 1 protein, DISC1, KIAA0457 |
Similar products |
DISC1, KIAA0457, Disrupted in schizophrenia 1 protein |
Lieferbar |
|
Immunogen Species |
Human |
UniprotID |
Q9NRI5 |
Immunogen |
Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA) |
Applications info |
ELISA, WB, IF, Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
WB:1:2000-1:10000 |
Dilution ratio 3 |
IF:1:50-1:200 |
Background |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. |
Conjugate |
Non-conjugated |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Neuroscience |
Initial Research Areas |
Neuroscience |
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