WNK3 Antibody, FITC conjugated

Polyclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Human

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.

>95%, Protein G purified

Signal Transduction

Recombinant Human Serine/threonine-protein kinase WNK3 protein (1018-1181AA)