ArtNr |
CSB-PA05369D0Rb-50ug |
Hersteller |
Cusabio
|
Menge |
50ug |
Quantity options |
100ug
50ug
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Biotin |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DKFZp686D0638 antibody; Glycogen synthase kinase 3 alpha antibody; Glycogen synthase kinase-3 alpha antibody; GSK 3 alpha antibody; GSK 3A antibody; GSK-3 alpha antibody; Gsk3a antibody; GSK3A_HUMAN antibody; GSK3alpha antibody; Serine/threonine protein kinase GSK3A antibody, Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1), GSK3A |
Similar products |
GSK3A, Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) |
Lieferbar |
|
Immunogen Species |
Human |
UniprotID |
P49840 |
Immunogen |
Recombinant Human Glycogen synthase kinase-3 alpha protein (36-118AA) |
Applications info |
ELISA |
Background |
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. |
Conjugate |
Biotin |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Cardiovascular, Cell biology, Signal transduction, Stem cells |
Initial Research Areas |
Cell Biology |
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